Massachusetts General Hospital
185 Cambridge Street
Boston MA 02114
Tel: (617) 724-1600
Fax: (617) 726-5057
Patricia K. Donahoe, M.D., is the Marshall K. Bartlett Professor of Surgery (HMS), Director Pediatric Surgical Laboratories (MGH), Associate Member of The Broad Institute, and a Principle Faculty Member at Harvard Stem Cell Institute. Her laboratory concentrates on developmental biology and genetics; including the study of sex differentiation and Mullerian Inhibiting Substance, Congenital Diaphragmatic Hernia, and other congenital anomalies. Her laboratory is also examining targetable differences between ovarian cancer stem cells and ovarian somatic stem cells.
- Donahoe PK, Noonan KM, Lage K. 2008. Systems Biology in Gene Discovery for Major Congenital Anomalies. BRDA; in press.
- Kantarci S, Donahoe P. 2007.Congenital diaphragmatic hernia (CHD) etiology as revealed by pathway genetics. Am J Med Gen 145C:217-226.
- Kantarci S, Al-Gazali L, Hill RS, Donnai D, Black GC, Bieth E, Chassaing N, Lacombe D, Devriendt K, Teebi A, Loscertales M, Robson C, Liu T, MacLaughlin DT, Noonan KM, Russell MK, Walsh CA, Donahoe PK, Pober BR. Mutations in LRP2, which encode the multiligand receptor megalin, cause Donnai-Barrow and facio-oculo-acoustico-renal syndromes. Nat Genet. 2007 Aug;39(8):957-9.
- Szotek PP, Pieretti-Vanmarcke R, Masiakos PT, Dinulescu DM, Connolly D, Foster R, Dombkowski D, Preffer F, Maclaughlin DT, Donahoe PK.Ovarian cancer side population defines cells with stem cell-like characteristics and Mullerian Inhibiting Substance responsiveness.Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11154-9.
BBS webpage updated 12/02/2009