BBS Faculty Member - George Daley

George Daley

Department of Biological Chemistry and Molecular Pharmacology, Pediatrics, and Medicine Investigator, Howard Hughes Medical Institute

Boston Children's Hospital
Karp Family Research Building 7214
One Blackfan Circle
Boston, MA 02115

Assistant:
Kathryn Entner
617-919-2015
kathryn.entner@childrens.harvard.edu

Tel: 617-919-2015
Email: george.daley@childrens.harvard.edu
Lab Members: 15 postdoctoral fellows, 10 graduate students

Our lab focuses on stem cell biology, with an emphasis on somatic cell reprogramming, hematopoietic differentiation from human and mouse pluripotent stem cells, and the role of the Lin28/let-7 pathway in human cancer and metabolic disease. Our subgroups study:

• The differentiation of hematopoietic (blood producing) stem cells from embryonic and induced pluripotent cells. We study hematopoietic development in mouse embryos and in human and mouse pluripotent stem cells to define the molecular genetic programs that enable formation of HSCs in experimental and therapeutic models.

• Derivation of personalized, patient-derived pluripotent stem cells: We use nuclear transfer, parthenogenesis, and reprogramming with defined genes to model combined cell and gene therapy of human genetic disorders.

• The Lin28/let-7 pathway: We have linked this ancient pathway, originally discovered in heterochronic mutants in C. elegans, to human cancer, germ cell development, and regulation of human growth and developmental timing. The pathway is also important in the function of stem cells, and in linking cancer cell proliferation and cellular metabolism.

Last Update: 1/17/2014

Publications

For a complete listing of publications click here.

Agarwal S, Loh Y-H, McLoughlin EM, Huang J, Park I-H, Miller JD, Huo H, Rosana Okuka M, Maria dos Reis RM, Loewer S, Ng, H-H, Keefe DL, Goldman FD, Klingelhutz AJ, Liu L, and Daley GQ. Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients. Nature 2010 464(7286):292-6.

Kim K, Doi A, Wen B, Ng K, Zhao R, Cahan P, Kim J, Aryee MJ, Ji H, Ehrlich L, Yabuuchi A, Takeuchi A, Cunniff KC, Hongguang H, Mckinney-Freeman S, Naveiras O, Yoon TJ, Irizarry RA, Jung N, Seita J, Hanna J, Jaenisch R, Weissleder R, Orkin SH, Weissman IL, Feinberg AP, and Daley GQ. Epigenetic memory in induced pluripotent stem cells. Nature 2010 467(7313):285-90.

Zhu H, Shyh-Chang N, Segrè AV, Shinoda G, Shah SP, Einhorn WS, Takeuchi A, Engreitz JM, Hagan JP, Kharas MG, Urbach A, Thornton JE, Triboulet R, Gregory RI; DIAGRAM Consortium; MAGIC Investigators, Altshuler D, Daley GQ. The Lin28/let-7 axis regulates glucose metabolism. Cell. 2011 147; 81-94.

Cherry ABC, Daley GQ. Reprogramming cellular identity for regenerative medicine. Cell 2012 Mar 16;148(6):1110-1122.

Onder TT, Kara N, Cherry ABC, Sinha AU, Zhu N, Bernt KM, Cahan P, Mancarci OB, Unternaehrer J, Gupta PB, Lander ES, Armstrong SA, Daley GQ. Chromatin modifying enzymes as modulators of reprogramming. Nature. 2012 Mar 4;483(7391):598-602.