BBS Faculty Member - George Daley

Faculty Listing

George Daley

Department of Biological Chemistry and Molecular Pharmacology, Pediatrics, and Medicine Investigator, Howard Hughes Medical Institute

Boston Children's Hospital
Karp Family Research Building 7214
One Blackfan Circle
Boston, MA 02115
Tel: 617-919-2015
Fax: 617-730-0222
Email: george.daley@childrens.harvard.edu
Lab Members: 15 postdoctoral fellows, 8 graduate students

Our lab focuses on stem cell biology, with an emphasis on somatic cell reprogramming, hematopoietic differentiation from human and mouse pluripotent stem cells, and common mechanisms in reprogramming and cancer. Our subgroups study:

• The differentiation of hematopoietic (blood producing) stem cells, platelets, red cells, and T cells from embryonic and induced pluripotent cells. We study hematopoietic development in mouse embryos and in human and mouse pluripotent stem cells to define the molecular genetic programs that enable formation of HSCs and transfusable blood products in experimental and therapeutic models.

• Derivation of personalized, patient-derived pluripotent stem cells: We use somatic cell reprogramming to establish human cell culture models of disease, and to model combined gene and cell transplantation therapy of human genetic disorders.

• The Lin28/let-7 pathway in reprogramming, human cancer and metabolic disease: We have linked this pathway to human cancer, germ cell development, and regulation of human growth and developmental timing. The pathway is also important in somatic cell reprogramming, and in linking cancer cell proliferation and cellular metabolism.

Last Update: 7/27/2015

Publications

For a complete listing of publications click here.

Onder TT, Kara N, Cherry ABC, Sinha AU, Zhu N, Bernt KM, Cahan P, Mancarci OB, Unternaehrer J, Gupta PB, Lander ES, Armstrong SA, Daley GQ. Chromatin modifying enzymes as modulators of reprogramming. Nature. 2012 Mar 4;483(7391):598-602.

Doulatov S, Vo LT, Chou SS, Kim PG, Arora N, Li H, Hadland BK, Bernstein ID, Collins JJ, Zon LI, Daley GQ. Induction of multipotential hematopoietic progenitors from human pluripotent stem cells via re-specification of lineage-restricted precursors. Cell Stem Cell 2013 Oct 3;13(4):459-70.

Morris SA, Cahan P, Li H#, Lu Y-F, Zhao AM, Sahalie J, San Roman AK, Shivdasani RA, Collins JJ, Daley GQ. Enhancing cellular engineering through network biology. Cell 2014 Aug 14;158(4):889-902.

Tu HC, Schwitalla S, Qian Z, LaPier GS, Yermalovich A, Ku YC, Chen SC, Viswanathan SR, Zhu H, Nishihara R, Inamura K, Kim SA, Morikawa T, Mima K, Sukawa Y, Yang J, Meredith G, Fuchs CS, Ogino S, Daley GQ. LIN28 cooperates with WNT signaling to drive invasive intestinal and colorectal adenocarcinoma in mice and humans. Genes Dev. 2015 May 15;29(10):1074-86.