BBS Faculty Member - George Church

George Church

Department of Genetics

Harvard Medical School
New Research Building, Room 238
77 Avenue Louis Pasteur
Boston, MA 02115
Tel: 617-432-7562
Fax: 617-432-6513
Lab Members: 18 postdoctoral fellows, 14 graduate students
Visit my lab page here.



Our research focuses on new technologies for genomic & proteomic measurement, synthesis and modeling of biomedical & ecological systems -- in particular, personal genomics and biofuels. We have developed next-generation sequencing methods to analyze the output of combinatorial selections as well as comprehensive gene-environment-trait data for affordable personalized medicine. We reprogram human skin-derived pluripotent skin cells to connect cis-regulatory motif variants in populations to allele-specific and cell-type-specific RNA measures and further to causal effects on cell and larger-scale morphologies. We are developing tools for connecting functional microbiomics with (VDJ-ome) immune responses.





Last Update: 8/21/2013



Publications

For a complete listing of publications click here.

 


 

Mali P, Yang L, Esvelt KM, Aach J, Guell M, DiCarlo JE, Norville JE, Church GM (2013) RNA-guided human genome engineering via Cas9. Science 339(6121):823-6.

Jewett MC, Fritz BR, Timmerman LE, Church GM (2013) In vitro integration of ribosomal RNA synthesis, ribosome assembly, and translation. Mol Syst Biol. 9:678

Alivisatos AP, Chun M, Church GM, Deisseroth K, Donoghue JP, Greenspan RJ, McEuen PL, Roukes ML, Sejnowski TJ, Weiss PS, Yuste R. (2013) The brain activity map. Science 339(6125):1284-5.

Ball MP, et al. (2012) A public resource facilitating clinical use of genomes. Proc Natl Acad Sci USA. 109(30):11920-7



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