BBS Faculty Member - Jon Aster

Jon Aster

Department of Pathology

Brigham and Women's Hospital
NRB Building, Room 652E
77 Avenue Louis Pasteur
Boston, MA 02115
Tel: 617-525-4370
Fax: 617-525-4422
Email: jaster@rics.bwh.harvard.edu



The Aster laboratory primarily studies Notch signaling in cancer. Ongoing projects seek to understand through use of ChIP-Seq and other comprehensive genome-wide approaches how Notch regulates the genomes of leukemia cells; how Notch activity is coordinated at the level of the genome with other transcription factors involved in T cell development and T cell transformation, as well as the components of the basal transcriptional machinery and regulators of histone marks; how post-translational modifications regulate Notch; and how Notch effects on leukemia cells are modified by interactions with bone marrow stromal cells. These studies are being conducted within the context of several multi-investigator projects, which foster close collaborations with investigators using structural, chemical, bioinformatic, and animal modeling approaches to study physiologic and pathophysiologic Notch signaling.







Last Update: 8/9/2013



Publications

For a complete listing of publications click here.

 


 

Weng AP, Ferrando AA, Lee W, Morris IV JP, Silverman LB, Sanchez-Irizarry C, Blacklow SC, Look AT, Aster JC. Activating mutations of NOTCH1 in T cell acute lymphoblastic leukemia. Science 2004; 306:269-71.

Chiang MY, Xu L, Shestova O, Histen G, L'Heureux S,
Aster JC*, Pear WS*. Leukemia-associated Notch1 alleles are weak tumor initiators, but impose Notch addiction on K-ras initiated leukemia. J Clin Invest 2008; 118:3181-94.
*co-corresponding authors

Ashworth TD, Pear WS, Chiang MY, Blacklow SC, Mastio J, Xu L, Kelliher M, Kastner P, Chan S,
Aster JC. Deletion-based mechanisms of Notch1 activation in T-ALL: Key roles for RAG recombinase and a conserved internal translational start site in Notch1. Blood 2010; 116:5455-5464.

Wang H, Zou JY, Zhao B, Johannsen E, Ashworth T, Wong H, Pear WS, Schug J, Blacklow SC, Arnett KL, Bernstein BE, Kieff E,
Aster JC. Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cells. PNAS, epublished July 7, 2011.



© 2013 by the President and Fellows of Harvard College