Zoltan P. Arany
Department of Medicine
Cardiovascular Institute - CLS 906
3 Blackfan Circle
Boston, MA 02115
Visit my lab page here.
The lab is interested in regulatory pathways that control cardiovascular metabolism. The heart and skeletal muscle are highly metabolically active tissues, and their rates of energy consumption, choice of substrates, and method of catabolism can vary widely. Aberrant generation or use of energy in these tissues leads to a great number of diseases, including diabetes, myopathy, and heart failure, and contributes to the aging process.
One focus of the lab has been on a small family of transcriptional regulators, the PGC-1 co-activators, which powerfully control numerous metabolic programs in different tissues, including the robust activation of mitochondrial biogenesis and function. Recently, we demonstrated that PGC-1s also regulates angiogenesis, thereby co-regulating neo-vascularization (oxygen delivery) with mitochondrial activity (oxygen consumption). We are taking multidisciplinary approaches, ranging from molecular biology and high-throughput genomics to cell biology and mouse physiology, to understanding how PGC-1s and other genetic regulators integrate metabolic homeostasis with vascular homeostasis in key metabolic tissues like heart and skeletal muscle.
A second focus of the lab is the study of paracrine factors, including members of the VEGF family, that regulate metabolism in heart and muscle. Current available projects include studying the role of endocrine effects on the vasculature in the development of peripartum cardiomyopathy, an uncommon but lethal heart failure that affects women in their prime, and for which no cause is known. Muscle itself is also increasingly appreciated to be capable of secreting “myokines” that can regulate function of adjacent cells (paracrine) or distant organs (endocrine). We have identified a number of novel functions for myokines and are studying their role in exercise and aging, and projects are also available in these areas.
For a complete listing of publications click here.
Last Update: 7/26/2012