Ed Kravitz, PhD

Olga Alekseyenko, PhD

David Bochner

Sarah Certel, PhD

Yick-Bun Chan, PhD

Adelaine Leung, PhD

Jill Penn, PhD

Joanne Yew, PhD

Adelaine Leung, Ph.D.

Post-doctoral Fellow

Email: adelaine_leung@hms.harvard.edu

Tel: 617-432-1042

I was a protein crystallographer interested in the structure and function of macromolecules. My first mentor was Dr. Albert Berghuis at McMaster University, Canada. Upon the completion of my Master’s degree, I moved to Dr. David Borhani’s laboratory in the Southern Research Institute at Birmingham, AL, where I was involved in the structure-based drug design effort. Two years later, I moved to Cambridge, UK to study for my Ph.D. at the MRC-Laboratory of Molecular Biology in the group of Dr. Kiyoshi Nagai. After my Ph.D., I decided to move beyond studying macromolecular structures to studying the structure and behavioural consequences of neural circuits. I joined the Kravitz Lab in January 2007. Using Drosophila melanogaster as a model organism, I would like to dissect the neural circuitry that governs aggressive behaviors.

Recent Publications:

1. Robert C. Reynolds, Shiela R. Campbell, Ralph G. Fairchild, Roy L. Kisliuk, Peggy L. Micca, Sherry F. Queener, James M. Riordan, W. David Sedwick, William R. Waud, Adelaine K.W. Leung, Richard W. Dixon, David W. Borhani, and William J. Suling (2007) Novel boron containing, nonclassical antifolates: synthesis and preliminary biological and structural evaluation. J. Med. Chem. 50, 3283-3289.

2. Leung, AK. and Nagai, K. (2005) Gemin 6 and 7 lend a hand to snRNP assembly. Structure, 13(6), 833-4.

3. Adelaine KW. Leung, White, LE., Ross, LJ, Reynolds, RC, DeVito, JA, Borhani, DW. (2004) Structure of Mycobacterium tuberculosis FtsZ Reveals Unexpected, G Protein-like Conformational Switches J Mol Biol., 342, 953-70.

4. David W. Borhani, David J. Calderwood, Michael M. Friedman, Gavin C. Hirst, Biqin Li, Adelaine KW. Leung, Brad McRae, Sheldon Ratnofsky, Kurt Ritter and Wendy Waegell (2004) A potent, orally active inhibitor of lck with efficacy in a model of transplant rejection Bioorganic & Medicinal Chemistry Letters, 14(10), 2613-2616.

5. David L. Burk, Wai-Ching Hon, Adelaine K.W. Leung, and Albert M. Berghuis (2001) Structural analyses of nucleotide binding to an aminoglycoside phosphotransferase. Biochemistry, 40, 8756-64.

6. Adelaine K.W. Leung, Henry S. Duewel, John F. Honek, and Albert M. Berghuis (2001) Crystal structure of the lytic transglycosylase from bacteriophage lambda in complexed with hexa-N-acetylchitohexaose. Biochemistry, 40, 5665 -5673.

7. Adelaine K.W. Leung, E. Lucile White, Larry J. Ross, and David W. Borhani (2000) Crystallization of the Mycobacterium tuberculosis cell-division protein FtsZ. Acta Cryst., D56, 1634-1637.

8. Leung, A.K.W., Park, M.M.V., and Borhani, D.W. (1999) An improved method for protein crystal density measurements. J. Appl. Cryst., 32, 1006-1009.