Curriculum Vitae for David C. Chiara
Washington University School of
Medicine, St. Louis, Missouri
Biomedical Sciences: Neuroscience (MSTP)
Defended January, 1996, Awarded concurrent with M.D. May 1997
Thesis Title: "Structural Studies of the Nicotinic Acetylcholine Receptor,
a Ligand-Gated Ion Channel"
Principal Investigator: Jonathan B. Cohen, Ph.D.
Sawyer, G.W., Chiara, D.C., Cohen, J.B. and Olsen, R.W. "Characterization
of the Site of Photoincorporation of [3H]Ro15-4513 into Affinity-Purified
GABAA Receptor a-Subunit" Society
for Neuroscience Abstracts, 2001 (pending)
Chiara, D.C., Eckenhoff, R.G., Dangott, L.J., and Cohen, J.B. "A Binding
Site for the Volatile Anesthetic Halothane within the Nicotinic Acetylcholine
Receptor Identified By Photoaffinity Labeling" Biophysical
Journal Abstracts, 2000, 78, 360A Abstract.
K.W. Miller, S.A. Forman, M.A. Kloczewaik, G.H. Addona, S.S. Husain,
D.C. Chiara, M.B. Pratt, and J.B. Cohen. "Sites of Anesthetic Action on
the Nicotinic Acetylcholine Receptor" Progress in Anesthetic Mechanism,
2000, 8. Abstract.
Chiara, D.C, Wang, D., Xie, Y., Trinidad, J.C., and Cohen, J.B. "Novel
Photoreactive Choline Esters as Probes of the Structure of the Nicotinic
Acetylcholine Receptor Agonist Binding Site" Protein
Science, 1999, 8, p70, 82-M, Abstract.
Miller, K.W., Addona, G.H., Chiara, D.C., Husain, S.S., Pratt, M.B.,
and Cohen, J.B. "Interactions of Anesthetics with the Nicotinic Acetylcholine
Receptor and Other Proteins," Archives
of Pharmacology, 1999, 359, R3.
Chiara, D.C., Addona, G.H., Kloczewiak, M.A., Cohen, J.B., and Miller,
K.W. "Time-Resolved Photolabeling of the Nicotinic Acetylcholine Receptor
Identifies the Site of Action of a Resting State Inhibitor," Biophysical
Journal Abstracts, 1999, 76, A372 Abstract.
Chiara, D.C. and Cohen, J.B., "Desensitization of the Torpedo Nicotinic
Acetylcholine Receptor (nAChR) Linked to Movement of the Agonist Site Residues
Trp-55 and Trp-57," Biophysical
Journal Abstracts, 1995, 68, A406 Abstract.
Xie, Y., Chiara, D.C., and Cohen, J.B., "Mutational Analysis of Novel
Residues Identified Within the Binding Site of d-Tubocurarine of Torpedo
Acetylcholine Receptor," Society for Neuroscience
Abstracts, 1994, 20, 466.5.
Cohen, J.B., Blanton, M.B., Chiara, D.C., Sharp, S.D., and White, B.H.
"Structural Organization of Functional Domains of the Nicotinic Acetylcholine
Receptor," J. Cell Biochem.,
Keystone Symposia on Molecular and Cellular Biology, 1992,
Chiara, D.C. and Cohen, J.B., " Identification of Amino Acids Contributing
to High and Low Affinity d-Tubocurarine (dTC) Sites on the Torpedo Nicotinic
Acetylcholine Receptor," Biophysical
Journal Abstracts, 1992, 61, A106 & FASEB
Journal Abstracts, 1992, 6, A106.
Chiara, D.C., Sacchettini, J.C., Frazier, M.W., Banaszak, L,J., and
Grant, G.A., "Structure of Porcine Heart Fumarase," The
Protein Society Symposium, Program and Abstracts, 1988, 2, S104.