Bruce A. Yankner, M.D., Ph.D.

Bruce A. Yankner, M.D., Ph.D.Bruce A. Yankner, M.D., Ph.D. is Professor of Genetics and Neurology at Harvard Medical School, Director of the Harvard Neurodegeneration Training Program, and Co-Director of the Paul F. Glenn Laboratories for the Molecular Biology of Aging. Dr. Yankner graduated from Princeton University, received his M.D. and Ph.D. from Stanford, and did his residency at the Massachusetts General Hospital. His work has contributed to the understanding of pathogenic mechanisms in Alzheimer’s disease, Down’s syndrome, Parkinson’s disease and diabetes. His recent work has focused on molecular features of the aging process in the brain, and has provided evidence for a genetic signature of brain aging characterized by changes in genes critical for learning and memory. He has received a number of awards, including the Major Award for Medical Research from the Metropolitan Life Foundation, the Derek Denny-Brown Neurological Scholar Award from the American Neurological Association, the Zenith Award from the Alzheimer’s Association, the Irving S. Cooper award from the Mayo Clinic, and the Ellison Medical Foundation Senior Scholar Award in Aging.

Direct Contact

Telephone: 617-432-6800
Lab Website:

Selected Publications

Zhang Z, Nadeau P, Song W, Donoviel D, Yuan M, Bernstein A and Yankner BA (2000). Presenilins are required for γ-secretase cleavage of b-APP and transmembrane cleavage of Notch-1. Nature Cell Biol. 2:463-465.

Lu T, Pan Y, Kao S-Y, Li C, Kohane I, Chan J and Yankner BA (2004). Gene regulation and DNA damage in the ageing human brain. Nature 429:833-891.

Hass M and Yankner BA (2005). A γ-secretase-independent mechanism of signal transduction by the amyloid precursor protein. J. Biol. Chem. 280: 36895-36904.