Marcia Haigis, Ph.D.

Marcia Haigis, Ph.D.Marcia C. Haigis, Ph.D. is an Associate Professor in the Department of Cell Biology at Harvard Medical School and a member of the Paul F. Glenn Center for Biology of Aging Research. Dr. Haigis received her Ph.D. in Biochemistry from the University of Wisconsin in 2002 studying protein chemistry. She performed postdoctoral research at MIT in 2006 where she made fundamental discoveries connecting sirtuin function to mitochondrial metabolism.  Dr. Haigis joined the Harvard faculty as an Assistant Professor in 2006.

The Haigis lab seeks to understand the role that mitochondria play in human aging and age-associated diseases. In particular, the lab uses cellular and mouse models to study the mitochondrial and metabolic responses to cellular stresses, such as DNA damage or nutrient challenge. Recent studies have identified roles for the sirtuin family of NAD-dependent deacylases in regulating the metabolic response to DNA damage. Additionally, the lab has used proteomic and metabolomic approaches to identify novel sirtuin targets, further defining how mitochondria adapt to stress.

In recognition of these scientific achievements, Dr. Haigis has received a Brookdale Leadership in Aging Award, the Ellison Medical Foundation New Scholar Award and an American Cancer Society Research Scholar Award.

Current Lab Members

Direct Contact

Marcia Haigis
Associate Professor
Department of Cell Biology
Harvard Medical School
SGM 329C
240 Longwood Avenue
Boston, MA 02115
Tel: 617-432-6865
Lab Website:

Selected Publications

Jeong SM, Haigis MC. Sirtuins in Cancer: a Balancing Act between Genome Stability and Metabolism. Mol Cells. 2015;38:750-758. Review. PMID: 26420294

Sage PT, Tan CL, Freeman GJ, Haigis M, Sharpe AH. Defective TFH Cell Function and Increased TFR Cells Contribute to Defective Antibody Production in Aging. Cell Rep. 2015;12:163-171. PMID: 26146074

German NJ, Haigis MC. Sirtuins and the Metabolic Hurdles in Cancer. Curr Biol. 2015;25:R569-583. Review. PMID: 26126285

Satterstrom FK, Swindell WR, Laurent G, Vyas S, Bulyk ML, Haigis MC. Nuclear respiratory factor 2 induces SIRT3 expression. Aging Cell. 2015;14:818-825. PMID: 26109058

Gonzalez Herrera KN, Lee J, Haigis MC. Intersections between mitochondrial sirtuin signaling and tumor cell metabolism. Crit Rev Biochem Mol Biol. 2015;50:242-255. PMID: 25898275

Ron-Harel N, Sharpe AH, Haigis MC. Mitochondrial metabolism in T cell activation and senescence: a mini-review. Gerontology. 2015;61:131-138. PMID: 25402204

LeBleu VS, O’Connell JT, Gonzalez Herrera KN, Wikman H, Pantel K, Haigis MC, de Carvalho FM, Damascena A, Domingos Chinen LT, Rocha RM, Asara JM, Kalluri R. PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis. Nat Cell Biol. 2014;16:992-1003. PMID: 25241037

Janzer A, German NJ, Gonzalez-Herrera KN, Asara JM, Haigis MC, Struhl K. Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells. Proc Natl Acad Sci U S A. 2014; 111:10574-10579. PMID: 25002509

Sinkevicius KW, Kriegel C, Bellaria KJ, Lee J, Lau AN, Leeman KT, Zhou P, Beede AM, Fillmore CM, Caswell D, Barrios J, Wong KK, Sholl LM, Schlaeger TM, Bronson RT, Chirieac LR, Winslow MM, Haigis MC, Kim CF. Neurotrophin receptor TrkB promotes lung adenocarcinoma metastasis. Proc Natl Acad Sci U S A. 2014; 111:10299-10304. PMID: 24982195

Satterstrom FK, Haigis MC. Luciferase-based reporter to monitor the transcriptional activity of the SIRT3 promoter. Methods Enzymol. 2014; 543:141-163. PMID: 24924131

Jeong SM, Lee J, Finley LW, Schmidt PJ, Fleming MD, Haigis MC. SIRT3 regulates cellular iron metabolism and cancer growth by repressing iron regulatory protein 1. Oncogene. 2014 Jun 9. [Epub ahead of print] PMID: 24909164

Jeong SM, Lee A, Lee J, Haigis MC. SIRT4 protein suppresses tumor formation in genetic models of Myc-induced B cell lymphoma. J Biol Chem. 2014; 289:4135-4144. PMID: 24368766

Jeong SM, Lee A, Lee J, Haigis MC. SIRT4 suppresses tumor formation in genetic models of Myc-induced B cell lymphoma. J Biol Chem. 2013 Dec 24. [Epub ahead of print] PMID: 24368766

Bause AS, Matsui MS, Haigis MC. The Protein Deacetylase SIRT3 Prevents Oxidative Stress-induced Keratinocyte Differentiation. J Biol Chem. 2013; 288:36484-36491. PMID: 24194516

Laurent G, de Boer VC, Finley LW, Sweeney M, Lu H, Schug TT, Cen Y, Jeong SM, Li X, Sauve AA, Haigis MC. SIRT4 represses peroxisome proliferator-activated receptor α activity to suppress hepatic fat oxidation. Mol Cell Biol. 2013; 33:4552-4561. PMID: 24043310

Yang MH, Laurent G, Bause AS, Spang R, German N, Haigis MC, Haigis KM. HDAC6 and SIRT2 regulate the acetylation state and oncogenic activity of mutant K-RAS. Mol Cancer Res. 2013; 11:1072-1077. PMID: 23723075

Laurent G., German NJ, Saha AK, de Boer VCJ, Davies M, Koves TR, Dephoure N, Fischer F, Boanca G, Vaitheesvaran B, Lovitch SB, Sharpe AH, Kurland IJ, Steegborn C, Gygi SP, Muoio DM, Ruderman NB, Haigis MC. SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl-CoA decarboxylase. Molecular Cell. 2013; 50:686-698. PMID: 23746352

Csibi A, Fendt SM, Li C, Poulogiannis G, Choo AY, Chapski DJ, Jeong SM, Dempsey JM, Parkhitko A, Morrison T, Henske EP, Haigis MC, Cantley LC, Stephanopoulos G, Yu J, Blenis J. The mTORC1 Pathway Stimulates Glutamine Metabolism and Cell Proliferation by Repressing SIRT4. Cell. 2013; 153:840-854. PMID: 23663782

Jeong SM, Xiao C, Finley LW, Lahusen T, Souza AL, Pierce K, Li YH, Wang X, Laurent G, German NJ, Xu X, Li C, Wang RH, Lee J, Csibi A, Cerione R, Blenis J, Clish CB, Kimmelman A, Deng CX, Haigis MC. SIRT4 Has Tumor-Suppressive Activity and Regulates the Cellular Metabolic Response to DNA Damage by Inhibiting Mitochondrial Glutamine Metabolism. Cancer Cell. 2013; 23:450-463. PMID: 23562301

Son J, Lyssiotis CA, Ying H, Wang X, Hua S, Ligorio M, Perera RM, Ferrone CR, Mullarky E, Shyh-Chang N, Kang Y, Fleming JB, Bardeesy N, Asara JM, Haigis MC, DePinho RA, Cantley LC, Kimmelman AC. Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway. Nature. 2013; 496:101-105. PMID: 23535601

Lee PC, Dodart JC, Aron L, Finley LW, Bronson RT, Haigis MC, Yankner BA, Harper JW. Altered Social Behavior and Neuronal Development in Mice Lacking the Uba6-Use1 Ubiquitin Transfer System. Mol Cell. 2013; 50:172-184. PMID: 23499007

Peserico A, Chiacchiera F, Grossi V, Matrone A, Latorre D, Simonatto M, Fusella A, Ryall JG, Finley LW, Haigis MC, Villani G, Puri PL, Sartorelli V, Simone C. A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels. Cell Mol Life Sci. 2013; 70:2015-2029. PMID: 23283301

Sebastian C, Satterstrom KF, Haigis MC, Mostoslavsky R. From Sirtuin biology to human diseases: an update. J Biol Chem. 2012; 287:42444-42452. Review. PMID: 23086954

Bause AS, Haigis MC. SIRT3 regulation of mitochondrial oxidative stress. Exp Gerontol. 2012; [Epub ahead of print] PMID: 22964489

Carracedo A, Weiss D, Leliaert AK, Bhasin M, de Boer VC, Laurent G, Adams AC, Sundvall M, Song SJ, Ito K, Finley LS, Egia A, Libermann T, Gerhart-Hines Z, Puigserver P, Haigis MC, Maratos-Flier E, Richardson AL, Schafer ZT, Pandolfi PP. A metabolic prosurvival role for PML in breast cancer. J Clin Invest. 2012; 122:3088-3100. PMID: 22886304

Inuzuka H, Gao D, Finley LW, Yang W, Wan L, Fukushima H, Chin YR, Zhai B, Shaik S, Lau AW, Wang Z, Gygi SP, Nakayama K, Teruya-Feldstein J, Toker A, Haigis MC, Pandolfi PP, Wei W. Acetylation-dependent regulation of Skp2 function. Cell. 2012; 150:179-193. PMID: 22770219

Finley LW, Haigis MC. Metabolic regulation by SIRT3: implications for tumorigenesis. Trends Mol Med. 2012; 18:516-523. PMID: 22749020

Yang MH, Nickerson S, Kim ET, Liot C, Laurent G, Spang R, Philips MR, Shan Y, Shaw DE, Bar-Sagi D, Haigis MC, Haigis KM. Regulation of RAS oncogenicity by acetylation. Proc Natl Acad Sci U S A. 2012; 109:10843-10848. PMID: 22711838

Haigis MC, Deng CX, Finley LW, Kim HS, Gius D. SIRT3 is a mitochondrial tumor suppressor: a scientific tale that connects aberrant cellular ROS, the Warburg effect, and carcinogenesis. Cancer Res. 2012; 72:2468-2472. PMID: 22589271

Cerletti M, Jang YC, Finley LW, Haigis MC, Wagers AJ. Short-term calorie restriction enhances skeletal muscle stem cell function. Cell Stem Cell. 2012; 10:515-519. PMID: 22560075

Garcia-Cao I, Song MS, Hobbs RM, Laurent G, Giorgi C, de Boer VC, Anastasiou D, Ito K, Sasaki AT, Rameh L, Carracedo A, Vander Heiden MG, Cantley LC, Pinton P, Haigis MC, Pandolfi PP. Systemic elevation of PTEN induces a tumor-suppressive metabolic state. Cell. 2012; 149:49-62. PMID: 22401813

Finley LW, Lee J, Souza A, Desquiret-Dumas V, Bullock K, Rowe GC, Procaccio V, Clish CB, Arany Z, Haigis MC. Skeletal muscle PGC-1alpha mediates mitochondrial, but not metabolic, adaptation to calorie restriction. Proc Natl Acad Sci U S A. 2012; 109:2931-2936. PMID: 22308395

De Raedt T, Walton Z, Lucas J, Li D, Chen Y, Maertens O, Jeong SM, Bronson RT, Normant E, Haigis MC, Manning BD, Wong KK, Macleod KF, and Cichowski K. Developing an mTOR-inhibitor based combination cancer therapy. Cancer Cell. 2011; 20:400-413. PMID 21907929.

Finley LW, Haas W, Desquiret-Dumas V, Wallace DC, Procaccio V, Gygi SP, Haigis MC. Succinate dehydrogenase is a direct target of sirtuin 3 deacetylase activity. PLoS One. 2011; 6:e23295. PMID: 21858060.

Yang S, Wang X, Contino G, Liesa M, Sahin E, Ying H, Bause A, Li Y, Stommel JM, Deill’antonio G, Mautner J, Tonon G, Haigis M, Shirihai OS, Doglioni C, Bardeesy N, Kimmelman AC. Pancreatic cancers require autophagy for growth. Genes Dev. 2011; 25:717-729. PMID 21406549.

Finley LW, Carracedo A, Lee J, Souza A, Egia A, Zhang J, Teruya-Feldstein J, Moreira PI, Cardosa SM, Clish CB, Pandolfi PP, Haigis MC. SIRT3 opposes reprogramming of cancer cell metabolism through HIF1alpha destabilization. Cancer Cell. 2011; 19:416-428. PMID: 21397863.

Haigis MC, Yankner BA. The aging stress response. Mol. Cell. 2010; 40:333-344. PMID: 20965426.

Haigis MC, Sinclair DA. Mammalian sirtuins: biological insights and disease relevance. Annu Rev Pathol. 2010; 5:253-295. PMID: 20078221.

Finley LS and Haigis MC. The coordination of nuclear and mitochondrial communication during aging and calorie restriction. Aging Research Reviews. 2009; 8:173-188.

Nakagawa T, Lomb D, Haigis MC, Guarente. SIRT5 deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle. Cell. 2009; 3:560-570.

Haigis KM, Kendall KR, Wang Y, Cheung A, Haigis MC, Glickman JN, Niwa-Kawakita M, Sweet-Cordero A, Sebolt-Leopold J, Shannon KM, Settleman J, Giovannini M, Jacks T. Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation, and tumor progression in the colon. Nature Genetics. 2008; 40:600-608.

Lombard DB, Alt FW, Cheng HL, Bunkenborg J, Streeper RS, Mostoslavsky R, Kim J, Yancopoulos G, Valenzuela D, Murphy A, Yang Y, Chen Y, Hirschey MD, Bronson RT, Haigis M, Guarente LP, Farese RV Jr, Weissman S, Verdin E, Schwer B. Mammalian Sir2 Homolog SIRT3 Regulates Global lysine acetylation. Mol Cell Biol. 2007; 27:8807-8814.

Haigis MC, Guarente L. Mammalian sirtuins-emerging roles in physiology, aging and calorie restriction. Genes and Development. 2006; 20:2913-2921.

Haigis MC, Mostoslavsky R, Haigis KM, Fahie K, Christodoulou DC, Murphy AJ, Valenzuela DM, Yancopoulos GD, Karow M, Blander G, Wolberger C, Prolla TA, Weindruch R, Alt FW, Guarente L. SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell. 2006; 126:941-954.

Blander G, Olejnik, Krzymanska-Olejnik, McDonagh T, Haigis MC, Yaffe M, Guarente L. SIRT1 shows no substrate specificity in vitro. Journal of Biological Chemistry. 2005; 280:9780-9785.

Leissring M, Farris W, Wu, Christodoulou D, Haigis MC, Guarente L, Selkoe D. Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria. Biochemical Journal. 2004; 116:313-324.

Lin SJ, Ford E, Haigis MC, Liszt G, Guarente L. Calorie restriction extends yeast life span by lowering the level of NADH. Genes and Development. 2004; 18:12-16.

Blander G, de Oliveira R, Conboy C, Haigis MC, Guarente L. Superoxide dismutase I knock-down induces senescence in human fibroblasts. Journal of Biological Chemistry. 2003; 278:38966-38969.