Faculty & Staff

David Sinclair, Ph.D.

David Sinclair, Ph.D.

David Sinclair, Ph.D. is Co-Director of the Paul F. Glenn Laboratories for the Molecular Biology of Aging, a Professor of Genetics at Harvard Medical School, Associate Member of the Broad Institute for Systems Biology, and co-founder of Sirtris Pharmaceuticals, Waltham, MA. Dr. Sinclair’s research aims to identify conserved longevity control pathways and devise small molecules that activate them, with a view to preventing and treating diseases caused by aging. His lab was the first to identify small molecules called STACs that can activate the SIRT pathway and extend lifespan of a diverse species. They also discovered key components of the aging regulatory pathway in yeast and is now focused on finding genes and STACs that extend the healthy lifespan of mice. More information →

Bruce A. Yankner, M.D., Ph.D.

Bruce A. Yankner, M.D., Ph.D.

Bruce A. Yankner, M.D., Ph.D. is Professor of Genetics and Neurology at Harvard Medical School, Director of the Harvard Neurodegeneration Training Program, and Co-Director of the Paul F. Glenn Laboratories for the Molecular Biology of Aging. Dr. Yankner graduated from Princeton University, received his M.D. and Ph.D. from Stanford, and did his residency at the Massachusetts General Hospital. His work has contributed to the understanding of pathogenic mechanisms in Alzheimer’s disease, Down’s syndrome, Parkinson’s disease and diabetes. His recent work has focused on molecular features of the aging process in the brain, and has provided evidence for a genetic signature of brain aging characterized by changes in genes critical for learning and memory. More information →

Marcia Haigis, Ph.D.

Marcia Haigis, Ph.D.

Assistant Professor of Cell Biology at Harvard Medical School. Dr. Haigis’s lab is focused on understanding the role that mitochondria play in mammalian aging and disease. Mitochondria are dynamic organelles that provide cells with energy even during dramatic changes in diet, stress and development. Mitochondria are also a major site for reactive oxygen species production, ion homeostasis, and apoptosis. Not surprisingly, mitochondrial dysfunction has been implicated in aging, neurodegeneration and metabolic diseases, such as diabetes. More information →

Amy J. Wagers, Ph.D.

Amy J. Wagers, Ph.D.

Amy J. Wagers is an Associate Professor of Stem Cell and Regenerative Biology at Harvard University and an Investigator in the Section on Islet Cell and Regenerative Biology at the Joslin Diabetes Center, and a recent member of the Paul F. Glenn Laboratories for the Biological Mechanisms of Aging at Harvard Medical School. Dr. Wagers received her Ph.D. in Immunology and Microbial Pathogenesis from Northwestern University, and completed postdoctoral training in stem cell biology at Stanford University. More information →