Associate Director for Resource and Collaborative Affairs
Associate Professor of Pathology
Chair, Division of Primate Resources
Research in the Division of Primate Resources has focused principally on the recognition of
spontaneously occurring infectious diseases of nonhuman primates and their development into
novel animal models to investigate disease pathogenesis. The division has been involved in the
initial description of several pathogens not previously recognized in nonhuman primates
including Enterocytozoon bieneusi, enteropathogenic E. coli and rhesus rhadinovirus.>
Recognition of such agents is critical in promoting colony health and in the development of
novel animal models of human infectious diseases. Of particular interest to the division has been
the study of opportunistic infections in simian AIDS and elucidating their impact on
gastrointestinal function, body composition and disease progression.
The Division's collaborative research program is a vital and dynamic component of the
overall research effort of the New England Primate Research Center and enables
investigators from other institutions to pursue their primate oriented research goals. This
program encompasses a broad range of research projects involving investigators from throughout
the nation and the world. We maintain an exemplary record
in fulfilling the mission of serving as a national resource to the biomedical research community.
In the years 1993-1997, 908 scientists representing 429 different institutions utilized the Center's
resources.
Goldin BR, Li W, Mansfield K, Woods M, Wanke C, Freeman L, Shevitz A,
Gualtieri L, Bussell S, Gorbach SL. The effect of micronutrient
supplementation of disease progression and death in SIV-infected
juvenile male rhesus macaques. J Infect Dis 2005; 192:311-18.
Greenough TC, Carville A, Coderre J, Somasundaran M, Sullivan JL,
Luzuriaga K, Mansfield KG. Pneumonitis and multi-organ system disease in
common marmosets (Callithrix jacchus) infected with the severe acute
respiratory syndrome-associated coronavirus. Am J Pathol. 2005;167:455-63.
Yearly J, Pearson C, Carville A, Shannon R, Mansfield KG, SIV-Associated
Myocarditis: Viral and Cellular Correlates of Inflammation Severity.
Journal of AIDS and Human Retroviruses 2006;22:529-40.
Yearley J, Pearson C, Shannon RP, Mansfield KG. Phenotypic variation in
myocardial macrophage populations suggests a role for macrophage
activation in SIV-associated cardiac disease. Journal of AIDS and Human Retroviruses 2007;23:515-24.
Mansfield KG, Angela Carville A, Lynn Wachtman L, Barry R. Goldin BR,
Yearley J, Li W, Woods M, Gualtieri L, Shannon R, and Wanke C. A Diet
high in saturated fat and cholesterol accelerates SIV disease progression. J Infect Dis 2007;196:1202-10.
Wachtman LM, Gualtieri L, Wanke C, Shannon R, Mansfield KG. Viral and host correlates of serum resistin in simian AIDS.
J AIDS and Hum Retroviruses, 2008 in press.
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